Cincinnati ? Ken Griffey Jr. will miss the rest of the season after hurting his right ankle Thursday night, the latest in a string of major injuries for the former All-Star.

The center fielder ruptured a tendon while running out a double in the sixth inning of the Cincinnati Reds’ 5-4 loss to the Houston Astros. Griffey stood at the plate for a moment, as if he thought his drive to left-center field would be a home run, and then he had to speed up.

Griffey appeared to hurt himself as he rounded first base. He had been bothered by a sore tendon for about a week and had been getting treatment before games.

The 33-year-old Griffey hit 13 home runs this year, raising his career total to 481 homers.

Going into Thursday’s game, Griffey had homered in the last five games in which he had an at-bat.

“It’s a shame,” Cincinnati manager Bob Boone said. “He was just starting to get his swing back. He was ready to take off.”

Once thought to be a threat to break Hank Aaron’s record of 755 career homers, Griffey has dropped from the game’s elite because of injuries.

He hit .247 with 26 RBIs in 53 games for the Reds this season.

Griffey will have surgery today at The Good Samaritan Hospital, the Reds said, with team physician Dr. Timothy Kremchek and foot and ankle specialist Dr. James Amis operating. Cincinnati said he also would have arthroscopic reconstructive surgery on his right shoulder in about two weeks.