Los Angeles ? Mark your %&! calendars the Ozzy Osbourne clan will be back Nov. 26 with the second season of their hit reality show, MTV announced Tuesday.

“The Osbournes” chronicles the lives of heavy metal rocker Ozzy, wife Sharon and two of their teenage children daughter Kelly and son Jack.

The show became the music channel’s biggest hit ever earlier this year, showcasing the family’s offbeat antics usually with a slew of obscenities.

The 10-episode season (9:30 p.m. CST Tuesdays, Sunflower Broadband Channel 57) will include Sharon Osbourne’s battle against colorectal cancer as she undergoes chemotherapy sessions.

“We are excited to invite the world into our home for another dose of Osbourne insanity. This season the show takes on a whole new meaning as we share the highs and the lows of the last six months with our viewers,” Sharon Osbourne said in a statement.

The family also has taken in a teenage friend of the family, Robert Marcato, whose mother died of the same kind of cancer afflicting Sharon Osbourne. Other new elements include Kelly’s nascent singing career and scenes at the Osbourne home in Malibu as well as their Beverly Hills house.

Brian Graden, president of entertainment for MTV and VH1, declined to predict whether ratings for “The Osbournes,” which won this year’s Emmy for best reality program, would be as high or how Sharon Osbourne’s health might affect viewership. But he added that he expects “The Osbournes” to be part of MTV “for a long time.”