The Botox backlash has begun.

Less than two months after the government approved the prescription drug as a temporary wrinkle-reliever for the brow turning a closet cosmetic of the rich into a tsunami-sized fad serious questions are being raised about its casual use.

Doctors, medical societies and patients are stepping forward to frown on blithe use of the toxin, especially at Botox parties.

“How voluntary and intelligent is an ‘informed consent’ that follows a glass or two of wine?” fretted New York City cosmetic plastic surgeon Paula Moynahan.

The American Academy of Dermatology and the American Society for Aesthetic Plastic Surgery have announced their disapproval of injecting Botox in “casual social settings.”

Some of the tsk-tsking smacks of turfism dermatologists and plastic surgeons are facing competition from the lucrative Botox beauty business. But there is no doubt that even in the best hands, the paralyzing poison can have unexpected results.

Consider Ruth Wittington, 46, of Southampton, Pa.

About 18 months ago, a dermatologist she consulted about a laser treatment suggested Botox for her forehead furrow. A week later, she said, both of her eyelids were so droopy that she had to lift the skin with her fingers to apply eyeshadow.

“For a couple months, I looked like I was sleepy all the time,” said Wittington, a mother of three who manages her husband’s plumbing business office.

The dermatologist, who refused a refund, suggested another try in three or four months, after the Botox wore off. But Wittington’s eyes had been opened, at least metaphorically: “Would I do it again? I’d have to be out of my mind!”