For the second straight week, it was a rough Sunday on NFL running backs.
Jamal Anderson, Ricky Watters, and Tiki Barber were sidelined, one week after Fred Taylor, Duce Staley and Garrison Hearst went down.
Atlanta's Anderson, who missed the 1999 season with torn right knee ligaments, was knocked out of Sunday's game against the Arizona Cardinals with a sprained left knee. Coach Dan Reeves said he believes it is serious.
"I think he's out for the year," Reeves said after the Falcons' 34-14 victory. "They think it's the ACL in the other knee. I don't think anybody touched him on this one, either."
Anderson will undergo an MRI today.
"This is supposed to be my good knee, so we'll see," Anderson said. "It doesn't feel like what happened to me before. I'm hoping I just have a bad sprain or it's hyperextended, maybe a partial tear."
Seattle's Watters left at Oakland in the first quarter with a sprained right shoulder. Watters had five rushes for 13 yards and one reception for 10 yards before getting injured. He removed his jersey on the sideline while getting treatment.
Barber, the tailback for the New York Giants, pulled a hamstring while making a 14-yard touchdown run during the second quarter against New Orleans. Barber jumped over a defender as he reached the pylon at the corner of the end zone, and seemed to grab for his left leg.
Barber has been injury prone of late. He broke his left arm late last season against Dallas. He also broke his right hand in training camp this year and did not play in any preseason games.
On his 6-yard TD run, Tampa Bay's Warrick Dunn reinjured the ankle he sprained earlier in the loss at Minnesota.
Oakland defensive end Trace Armstrong might have a ruptured right Achilles' tendon, an injury that would end the Pro Bowl selection's season.
Armstrong, who led the league in sacks with Miami last season, remained on the field after several players cleared a pileup near Oakland's goal line, and had to be helped off. He will be re-examined today.
Jacksonville's Mark Brunell left with a concussion from a blow to the head by Cleveland's Gerard Warren. On Jacksonville's first offensive play, Warren blocked Brunell after the quarterback threw an interception.