Firefighters were called just before 9 a.m. Wednesday to a ranch-style home at 1522 Harper when a neighbor saw smoke coming from the home.
Neighbors say the current owner lives in a nursing home and was using the house for storage. No one was at home.
Neighbors thought the fire may have begun in the garage where most items were stored.
Firefighters were still at the scene this morning. The Lawrence fire department said the cause is still unknown.