Joey Harrington threw two first-half touchdown passes, and Oregon's defense made the points hold up as the Ducks took control of the race for the Rose Bowl.
Oregon (6-1, 4-0 Pac-10), the only unbeaten team left in the conference, won its 19th straight home game by holding Arizona to just 17 rushing yards on 32 carries.
The Wildcats (5-2, 3-1) didn't fare much better with quarterback Ortege Jenkins. He was sacked eight times, and a second-quarter interception led to a touchdown that put the Ducks ahead 14-0.
Arizona fell to 0-5 under coach Dick Tomey at Autzen Stadium, the only Pac-10 stadium in which he's never won during his 13-plus seasons with the Wildcats. Arizona hasn't won here since 1986.
No. 13 Miss. State 38, OT
Baton Rouge, La. LSU's LaBrandon Toefield scored on a 13-yard run on the first possession of overtime.
LSU then held Mississippi State on a fourth-and-two from the 17. Wayne Madkin tried to scramble for a first down, but was stopped well short by Jeremy Lawrence and Teverance Faulk.
Toefield finished with 119 yards and two touchdowns, as LSU (5-3, 3-2 SEC) gained 220 yards on the ground against a Mississippi State run defense that entered the game No. 1 in the country, allowing 24 yards per game.